Evaluation of adjunctive systemic doxycycline with non-surgical periodontal therapy within type 2 diabetic patients

To evaluate the effects of systemic doxycycline on clinical and microbiological parameters of diabetic subjects with chronic periodontitis. This 9-month multi-center, randomized, parallel, single-blinded study was conducted from different hospitals in Riyadh, Saudi Arabia between April 2010 and December 2010. A total of 76 diabetic subjects with chronic periodontitis were randomized into 2 groups: control group [CG] received only scaling and root planing [SRP], and the treatment group [TG] receiving systemic doxycycline during the reevaluation visit 45 days after the completion of SRP. Probing pocket depth, clinical attachment level, gingival index, plaque index, and bleeding on probing were collected at baseline, 45 days after SRP, and one, 3, and 6 months after the use of systemic doxycycline. Microbiological analysis comprised the detection of Tannerella forsythia [Tf], Aggregatibacter actinomycetemcomitans [Aa], Porphyromonas gingivalis [Pg], and Prevotella intermedia [Pi] by polymerase chain reaction method. Sixty-eight [33 CG and 35 TG] subjects completed the study. Greater reduction in the population of Tf, Pg, and Pi were observed in TG compared with CG in the first month after the administration of systemic doxycycline. The TG showed a significant improvement in gingival index scores compared with the CG [p<0.05] by the end of the first and 6 months after the administration of doxycycline. Adjunct systemic doxycycline can be associated with a reduction of Tf, Pg, and Pi in the first month after the administration of doxycycline with an improvement in the GI

Determinants of periodontopathogens in microbiological monitoring of diabetic patients with periodontitis

To determine and analyze the frequency of periodontopathogens in microbiological monitoring of diabetic patients with periodontitis. This cross-sectional study included 352 diabetic patients with periodontitis who were registered at Riyadh Armed Forces Hospital, King Faisal Specialist Hospital and Research Centre, King Abdul Aziz Medical City, Naval Base Hospital, and Sultan Bin Adulaziz Humanitarian City, Riyadh, Kingdom of Saudi Arabia from July 2004 to August 2008. Microbiological analysis comprised the detection of Bacteroides forsythus [Bf], Aggregatibacter actinomycetemcomitans [Aa], Porphyromonas gingivalis [Pg], and Prevotella intermedia [Pi] by polymerase chain reaction method. The mean age of patients was 54.4 +/- 0.67 [range: 21-80 years]. There were 214 [61%] males and 138 [39%] females. Among the study population, 36 [10%] had type 1, and 316 [90%] patients had type 2 diabetes. The results showed that 55.6% of patients had Bf, 51.7% had Az, 63.7% had Pg, and 6.1% had Pi. The frequencies of periodontopathogens were higher in males than females in all age groups. The risk of periodontopathogens Bf were found higher level in 41-50 age group, Aa in 51-60, Pg in 51-60, and Pi in 31-40 age groups. This study found that the frequencies of periodontal pathogens Bf, Aa, and Pg were higher than Pi in diabetic patients with periodontitis